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Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs

Formylglycine‐generating enzymes specifically oxidize cysteine within the consensus sequence CxPxR to C(α)‐formylglycine (FGly). This noncanonical electrophilic amino acid can subsequently be addressed selectively by bioorthogonal hydrazino‐iso‐Pictet‐Spengler (HIPS) or Knoevenagel ligation to attac...

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Detalles Bibliográficos
Autores principales:	Janson, Nils, Krüger, Tobias, Karsten, Lennard, Boschanski, Mareile, Dierks, Thomas, Müller, Kristian M., Sewald, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756428/ https://www.ncbi.nlm.nih.gov/pubmed/32767537 http://dx.doi.org/10.1002/cbic.202000416

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