Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics

Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti‐infective effects have been confirmed. Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant drug targets of severe acute respirato...

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Detalles Bibliográficos
Autores principales: Gil‐Moles, Maria, Basu, Uttara, Büssing, Rolf, Hoffmeister, Henrik, Türck, Sebastian, Varchmin, Agnieszka, Ott, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756435/
https://www.ncbi.nlm.nih.gov/pubmed/32915473
http://dx.doi.org/10.1002/chem.202004112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756435/
https://www.ncbi.nlm.nih.gov/pubmed/32915473
http://dx.doi.org/10.1002/chem.202004112

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