A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesize...

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Detalles Bibliográficos
Autores principales: Maccallini, Cristina, Marinelli, Lisa, Indorf, Patrick, Cacciatore, Ivana, Fantacuzzi, Marialuigia, Clement, Bernd, Di Stefano, Antonio, Amoroso, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756445/
https://www.ncbi.nlm.nih.gov/pubmed/32783298
http://dx.doi.org/10.1002/cmdc.202000349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756445/
https://www.ncbi.nlm.nih.gov/pubmed/32783298
http://dx.doi.org/10.1002/cmdc.202000349

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