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A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice
OBJECTIVE: Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease‐modifying treatments are approved. A key therapeutic target in PD is α‐synuclein (αS), which is both genetically implicated and accumulates in Lewy bodies ri...
Autores principales: | Nuber, Silke, Nam, Alice Y., Rajsombath, Molly M., Cirka, Haley, Hronowski, Xiaoping, Wang, Junmin, Hodgetts, Kevin, Kalinichenko, Liubov S., Müller, Christian P., Lambrecht, Vera, Winkler, Jürgen, Weihofen, Andreas, Imberdis, Thibaut, Dettmer, Ulf, Fanning, Saranna, Selkoe, Dennis J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756464/ https://www.ncbi.nlm.nih.gov/pubmed/32996158 http://dx.doi.org/10.1002/ana.25920 |
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