Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

Hemiasterlin is an antimitotic marine natural product with reported sub‐nanomolar potency against several cancer cell lines. Herein, we describe an expeditious total synthesis of hemiasterlin featuring a four‐component Ugi reaction (Ugi‐4CR) as the key step. The convergent synthetic strategy enabled...

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Detalles Bibliográficos
Autores principales: Charoenpattarapreeda, Jiraborrirak, Walsh, Stephen J., Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756509/
https://www.ncbi.nlm.nih.gov/pubmed/32894646
http://dx.doi.org/10.1002/anie.202010090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756509/
https://www.ncbi.nlm.nih.gov/pubmed/32894646
http://dx.doi.org/10.1002/anie.202010090

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