The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics

Drug discovery, in particular optimization of candidates using medicinal chemistry, is generally guided by structural biology. However, for optimizing binding kinetics, relevant for efficacy and off‐target effects, information on protein motion is important. Herein, we demonstrate for the prototypic...

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Detalles Bibliográficos
Autores principales: Singh, Himanshu, Das, Chandan K., Vasa, Suresh K., Grohe, Kristof, Schäfer, Lars V., Linser, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756556/
https://www.ncbi.nlm.nih.gov/pubmed/32965765
http://dx.doi.org/10.1002/anie.202009348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756556/
https://www.ncbi.nlm.nih.gov/pubmed/32965765
http://dx.doi.org/10.1002/anie.202009348

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