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The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics
Drug discovery, in particular optimization of candidates using medicinal chemistry, is generally guided by structural biology. However, for optimizing binding kinetics, relevant for efficacy and off‐target effects, information on protein motion is important. Herein, we demonstrate for the prototypic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756556/ https://www.ncbi.nlm.nih.gov/pubmed/32965765 http://dx.doi.org/10.1002/anie.202009348 |