Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogues, in which the γ‐phosphate was modified covalently by lipophilic alkyl residues, and acyloxybenzyl prodrugs of thes...

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Detalles Bibliográficos
Autores principales: Zhao, Chenglong, Weber, Stefan, Schols, Dominique, Balzarini, Jan, Meier, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756582/
https://www.ncbi.nlm.nih.gov/pubmed/32379948
http://dx.doi.org/10.1002/anie.202003073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756582/
https://www.ncbi.nlm.nih.gov/pubmed/32379948
http://dx.doi.org/10.1002/anie.202003073

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