Hydroxamic Acids Immobilized on Resins (HAIRs): Synthesis of Dual‐Targeting HDAC Inhibitors and HDAC Degraders (PROTACs)

Inhibition of more than one cancer‐related pathway by multi‐target agents is an emerging approach in modern anticancer drug discovery. Here, based on the well‐established synergy between histone deacetylase inhibitors (HDACi) and alkylating agents, we present the discovery of a series of alkylating...

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Detalles Bibliográficos
Autores principales: Sinatra, Laura, Bandolik, Jan J., Roatsch, Martin, Sönnichsen, Melf, Schoeder, Clara T., Hamacher, Alexandra, Schöler, Andrea, Borkhardt, Arndt, Meiler, Jens, Bhatia, Sanil, Kassack, Matthias U., Hansen, Finn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756583/
https://www.ncbi.nlm.nih.gov/pubmed/32780485
http://dx.doi.org/10.1002/anie.202006725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756583/
https://www.ncbi.nlm.nih.gov/pubmed/32780485
http://dx.doi.org/10.1002/anie.202006725

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