Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing

Auristatins are a class of ultrapotent microtubule inhibitors, whose growing clinical popularity in oncology is based upon their use as payloads in antibody‐drug conjugates (ADCs). The most widely utilized auristatin, MMAE, has however been shown to cause apoptosis in non‐pathological cells proximal...

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Detalles Bibliográficos
Autores principales: Hartmann, Rafael W., Fahrner, Raphael, Shevshenko, Denys, Fyrknäs, Mårten, Larsson, Rolf, Lehmann, Fredrik, Odell, Luke R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756782/
https://www.ncbi.nlm.nih.gov/pubmed/33063934
http://dx.doi.org/10.1002/cmdc.202000497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756782/
https://www.ncbi.nlm.nih.gov/pubmed/33063934
http://dx.doi.org/10.1002/cmdc.202000497

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