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A review of linc00673 as a novel lncRNA for tumor regulation

Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as...

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Autores principales: Zhu, Kunjie, Gong, Zhaojian, Li, Panchun, Jiang, Xianjie, Zeng, Zhaoyang, Xiong, Wei, Yu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757132/
https://www.ncbi.nlm.nih.gov/pubmed/33390809
http://dx.doi.org/10.7150/ijms.48134
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author Zhu, Kunjie
Gong, Zhaojian
Li, Panchun
Jiang, Xianjie
Zeng, Zhaoyang
Xiong, Wei
Yu, Jianjun
author_facet Zhu, Kunjie
Gong, Zhaojian
Li, Panchun
Jiang, Xianjie
Zeng, Zhaoyang
Xiong, Wei
Yu, Jianjun
author_sort Zhu, Kunjie
collection PubMed
description Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as an oncogene or tumor suppressor gene, is closely related to the occurrence and development of tumors. Linc00673 is a recently discovered LncRNA molecule that is dysregulated in several solid tumors. Moreover, its genetic polymorphism is believed to affect the susceptibility of a population to the corresponding cancer species. This article summarizes the role of Linc00673 in different human cancers and its molecular mechanisms with a focus on the characteristics of Linc00673 and the existing literature on it while highlighting the future research directions for Linc00673. Linc00673 has the potential to become a feasible clinical diagnostic and prognostic marker toward providing a new molecular therapeutic target for cancer patients.
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spelling pubmed-77571322021-01-01 A review of linc00673 as a novel lncRNA for tumor regulation Zhu, Kunjie Gong, Zhaojian Li, Panchun Jiang, Xianjie Zeng, Zhaoyang Xiong, Wei Yu, Jianjun Int J Med Sci Review Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as an oncogene or tumor suppressor gene, is closely related to the occurrence and development of tumors. Linc00673 is a recently discovered LncRNA molecule that is dysregulated in several solid tumors. Moreover, its genetic polymorphism is believed to affect the susceptibility of a population to the corresponding cancer species. This article summarizes the role of Linc00673 in different human cancers and its molecular mechanisms with a focus on the characteristics of Linc00673 and the existing literature on it while highlighting the future research directions for Linc00673. Linc00673 has the potential to become a feasible clinical diagnostic and prognostic marker toward providing a new molecular therapeutic target for cancer patients. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757132/ /pubmed/33390809 http://dx.doi.org/10.7150/ijms.48134 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhu, Kunjie
Gong, Zhaojian
Li, Panchun
Jiang, Xianjie
Zeng, Zhaoyang
Xiong, Wei
Yu, Jianjun
A review of linc00673 as a novel lncRNA for tumor regulation
title A review of linc00673 as a novel lncRNA for tumor regulation
title_full A review of linc00673 as a novel lncRNA for tumor regulation
title_fullStr A review of linc00673 as a novel lncRNA for tumor regulation
title_full_unstemmed A review of linc00673 as a novel lncRNA for tumor regulation
title_short A review of linc00673 as a novel lncRNA for tumor regulation
title_sort review of linc00673 as a novel lncrna for tumor regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757132/
https://www.ncbi.nlm.nih.gov/pubmed/33390809
http://dx.doi.org/10.7150/ijms.48134
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