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A review of linc00673 as a novel lncRNA for tumor regulation
Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757132/ https://www.ncbi.nlm.nih.gov/pubmed/33390809 http://dx.doi.org/10.7150/ijms.48134 |
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author | Zhu, Kunjie Gong, Zhaojian Li, Panchun Jiang, Xianjie Zeng, Zhaoyang Xiong, Wei Yu, Jianjun |
author_facet | Zhu, Kunjie Gong, Zhaojian Li, Panchun Jiang, Xianjie Zeng, Zhaoyang Xiong, Wei Yu, Jianjun |
author_sort | Zhu, Kunjie |
collection | PubMed |
description | Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as an oncogene or tumor suppressor gene, is closely related to the occurrence and development of tumors. Linc00673 is a recently discovered LncRNA molecule that is dysregulated in several solid tumors. Moreover, its genetic polymorphism is believed to affect the susceptibility of a population to the corresponding cancer species. This article summarizes the role of Linc00673 in different human cancers and its molecular mechanisms with a focus on the characteristics of Linc00673 and the existing literature on it while highlighting the future research directions for Linc00673. Linc00673 has the potential to become a feasible clinical diagnostic and prognostic marker toward providing a new molecular therapeutic target for cancer patients. |
format | Online Article Text |
id | pubmed-7757132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-77571322021-01-01 A review of linc00673 as a novel lncRNA for tumor regulation Zhu, Kunjie Gong, Zhaojian Li, Panchun Jiang, Xianjie Zeng, Zhaoyang Xiong, Wei Yu, Jianjun Int J Med Sci Review Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as an oncogene or tumor suppressor gene, is closely related to the occurrence and development of tumors. Linc00673 is a recently discovered LncRNA molecule that is dysregulated in several solid tumors. Moreover, its genetic polymorphism is believed to affect the susceptibility of a population to the corresponding cancer species. This article summarizes the role of Linc00673 in different human cancers and its molecular mechanisms with a focus on the characteristics of Linc00673 and the existing literature on it while highlighting the future research directions for Linc00673. Linc00673 has the potential to become a feasible clinical diagnostic and prognostic marker toward providing a new molecular therapeutic target for cancer patients. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757132/ /pubmed/33390809 http://dx.doi.org/10.7150/ijms.48134 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhu, Kunjie Gong, Zhaojian Li, Panchun Jiang, Xianjie Zeng, Zhaoyang Xiong, Wei Yu, Jianjun A review of linc00673 as a novel lncRNA for tumor regulation |
title | A review of linc00673 as a novel lncRNA for tumor regulation |
title_full | A review of linc00673 as a novel lncRNA for tumor regulation |
title_fullStr | A review of linc00673 as a novel lncRNA for tumor regulation |
title_full_unstemmed | A review of linc00673 as a novel lncRNA for tumor regulation |
title_short | A review of linc00673 as a novel lncRNA for tumor regulation |
title_sort | review of linc00673 as a novel lncrna for tumor regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757132/ https://www.ncbi.nlm.nih.gov/pubmed/33390809 http://dx.doi.org/10.7150/ijms.48134 |
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