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Inactivation of HIF‐prolyl 4‐hydroxylases 1, 2 and 3 in NG2‐expressing cells induces HIF2‐mediated neurovascular expansion independent of erythropoietin
AIM: NG2 cells in the brain are comprised of pericytes and NG2 glia and play an important role in the execution of cerebral hypoxia responses, including the induction of erythropoietin (EPO) in pericytes. Oxygen‐dependent angiogenic responses are regulated by hypoxia‐inducible factor (HIF), the acti...
Autores principales: | Urrutia, Andrés A., Guan, Nan, Mesa‐Ciller, Claudia, Afzal, Aqeela, Davidoff, Olena, Haase, Volker H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757172/ https://www.ncbi.nlm.nih.gov/pubmed/32846048 http://dx.doi.org/10.1111/apha.13547 |
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