Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2

Common laboratory mice such as BALB/c and C57BL/6 mice are not permissive to SARS-CoV2 infection. Sensitization of laboratory mice with Adenovirus expressing human ACE2 (Ad5-hACE2) provides a rapid model for testing viral intervention in vivo. Despite the lack of lethal outcome, Ad5-hACE2-sensitized...

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Detalles Bibliográficos
Autores principales: Wong, Lok-Yin Roy, Li, Kun, Sun, Jing, Zhuang, Zhen, Zhao, Jincun, McCray, Paul B., Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757354/
https://www.ncbi.nlm.nih.gov/pubmed/33377063
http://dx.doi.org/10.1016/j.xpro.2020.100169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757354/
https://www.ncbi.nlm.nih.gov/pubmed/33377063
http://dx.doi.org/10.1016/j.xpro.2020.100169

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