LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient

Nucleocytoplasmic transport (NCT) defects have been implicated in neurodegenerative diseases such as C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). Here, we identify a neuroprotective pathway of like-Sm protein 12 (LSM12) and exchange protein directly acti...

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Detalles Bibliográficos
Autores principales: Lee, Jongbo, Park, Jumin, Kim, Ji-hyung, Lee, Giwook, Park, Tae-Eun, Yoon, Ki-Jun, Kim, Yoon Ki, Lim, Chunghun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757817/
https://www.ncbi.nlm.nih.gov/pubmed/33362237
http://dx.doi.org/10.1371/journal.pbio.3001002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757817/
https://www.ncbi.nlm.nih.gov/pubmed/33362237
http://dx.doi.org/10.1371/journal.pbio.3001002

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