Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel

CLC-0, a prototype Cl(-) channel in the CLC family, employs two gating mechanisms that control its ion-permeation pore: fast gating and slow gating. The negatively-charged sidechain of a pore glutamate residue, E166, is known to be the fast gate, and the swinging of this sidechain opens or closes th...

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Detalles Bibliográficos
Autores principales: Kwon, Hwoi Chan, Yu, Yawei, Fairclough, Robert H., Chen, Tsung-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757909/
https://www.ncbi.nlm.nih.gov/pubmed/33362212
http://dx.doi.org/10.1371/journal.pone.0240704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757909/
https://www.ncbi.nlm.nih.gov/pubmed/33362212
http://dx.doi.org/10.1371/journal.pone.0240704

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