Demographic history mediates the effect of stratification on polygenic scores

Population stratification continues to bias the results of genome-wide association studies (GWAS). When these results are used to construct polygenic scores, even subtle biases can cumulatively lead to large errors. To study the effect of residual stratification, we simulated GWAS under realistic mo...

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Detalles Bibliográficos
Autores principales: Zaidi, Arslan A, Mathieson, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758063/
https://www.ncbi.nlm.nih.gov/pubmed/33200985
http://dx.doi.org/10.7554/eLife.61548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758063/
https://www.ncbi.nlm.nih.gov/pubmed/33200985
http://dx.doi.org/10.7554/eLife.61548

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