Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is...

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Detalles Bibliográficos
Autores principales: Preissler, Steffen, Rato, Claudia, Yan, Yahui, Perera, Luke A, Czako, Aron, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758071/
https://www.ncbi.nlm.nih.gov/pubmed/33295873
http://dx.doi.org/10.7554/eLife.62601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758071/
https://www.ncbi.nlm.nih.gov/pubmed/33295873
http://dx.doi.org/10.7554/eLife.62601

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