Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells

There are indications that pharmacological doses of ascorbate (Asc) used as an adjuvant improve the chemotherapeutic management of cancer. This favorable outcome stems from its cytotoxic effects due to prooxidative mechanisms. Since regulation of intracellular Ca(2+) levels contributes to the mainte...

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Detalles Bibliográficos
Autores principales: Oronowicz, Jakub, Reinhard, Jacqueline, Reinach, Peter Sol, Ludwiczak, Szymon, Luo, Huan, Omar Ba Salem, Marah Hussain, Kraemer, Miriam Monika, Biebermann, Heike, Kakkassery, Vinodh, Mergler, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758186/
https://www.ncbi.nlm.nih.gov/pubmed/32948812
http://dx.doi.org/10.1038/s41374-020-00485-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758186/
https://www.ncbi.nlm.nih.gov/pubmed/32948812
http://dx.doi.org/10.1038/s41374-020-00485-2

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