Cargando…

Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease

Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutr...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Tianting, Zhan, Zhen, Zhang, Liang, Zhu, Jun, Liu, Yi, Zhang, Lili, Ge, Jianchao, Zhao, Ying, Zhang, Li, Dong, Jingde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758281/
https://www.ncbi.nlm.nih.gov/pubmed/33362679
http://dx.doi.org/10.3389/fneur.2020.533731
_version_ 1783626907269464064
author Yang, Tianting
Zhan, Zhen
Zhang, Liang
Zhu, Jun
Liu, Yi
Zhang, Lili
Ge, Jianchao
Zhao, Ying
Zhang, Li
Dong, Jingde
author_facet Yang, Tianting
Zhan, Zhen
Zhang, Liang
Zhu, Jun
Liu, Yi
Zhang, Lili
Ge, Jianchao
Zhao, Ying
Zhang, Li
Dong, Jingde
author_sort Yang, Tianting
collection PubMed
description Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutrition/already malnourished. Questionnaires, physical examinations, and biochemical tests were conducted. The relationship between nutrition status and PD was analyzed using t-tests, χ(2)-tests, and logistic regression models. Results: The prevalence of malnutrition [defined as a Mini Nutritional Assessment (MNA) score <17] was 39.2%, and 30.3% of patients were at risk of malnutrition (17 ≤ MNA score ≤ 23.5). There was no difference in gender and age between the different nutrition groups (P < 0.05). Patients at risk of malnutrition and those who were malnourished had a longer course of disease, more severe motor symptoms, a higher stage of PD according to the Hoehn and Yahr (H-Y) classification, a lower body mass index (BMI) index, a lower cognitive score, higher levels of depression and anxiety, and more serious non-motor symptoms (P < 0.05) than patients with normal nutrition. There were differences in adenosine deaminase, albumin, phosphorus, chlorine, total protein, and uric acid between the two groups (P < 0.05). High Unified PD Rating Scale (UPDRS-III) scores, high H-Y stages, and dyskinesia were risk factors for malnutrition in PD patients, while high levels of total protein, uric acid, and chlorine were protective factors that led to good nutrition (P < 0.05). Conclusions: Our results showed that dyskinesia, disease severity, total protein levels, uric acid levels, and chlorine levels were associated with nutritional status among Chinese PD patients. The findings of this study indicate the significance of the early detection and prevention of malnutrition to improve the quality of life of PD patients.
format Online
Article
Text
id pubmed-7758281
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77582812020-12-25 Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease Yang, Tianting Zhan, Zhen Zhang, Liang Zhu, Jun Liu, Yi Zhang, Lili Ge, Jianchao Zhao, Ying Zhang, Li Dong, Jingde Front Neurol Neurology Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutrition/already malnourished. Questionnaires, physical examinations, and biochemical tests were conducted. The relationship between nutrition status and PD was analyzed using t-tests, χ(2)-tests, and logistic regression models. Results: The prevalence of malnutrition [defined as a Mini Nutritional Assessment (MNA) score <17] was 39.2%, and 30.3% of patients were at risk of malnutrition (17 ≤ MNA score ≤ 23.5). There was no difference in gender and age between the different nutrition groups (P < 0.05). Patients at risk of malnutrition and those who were malnourished had a longer course of disease, more severe motor symptoms, a higher stage of PD according to the Hoehn and Yahr (H-Y) classification, a lower body mass index (BMI) index, a lower cognitive score, higher levels of depression and anxiety, and more serious non-motor symptoms (P < 0.05) than patients with normal nutrition. There were differences in adenosine deaminase, albumin, phosphorus, chlorine, total protein, and uric acid between the two groups (P < 0.05). High Unified PD Rating Scale (UPDRS-III) scores, high H-Y stages, and dyskinesia were risk factors for malnutrition in PD patients, while high levels of total protein, uric acid, and chlorine were protective factors that led to good nutrition (P < 0.05). Conclusions: Our results showed that dyskinesia, disease severity, total protein levels, uric acid levels, and chlorine levels were associated with nutritional status among Chinese PD patients. The findings of this study indicate the significance of the early detection and prevention of malnutrition to improve the quality of life of PD patients. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758281/ /pubmed/33362679 http://dx.doi.org/10.3389/fneur.2020.533731 Text en Copyright © 2020 Yang, Zhan, Zhang, Zhu, Liu, Zhang, Ge, Zhao, Zhang and Dong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Yang, Tianting
Zhan, Zhen
Zhang, Liang
Zhu, Jun
Liu, Yi
Zhang, Lili
Ge, Jianchao
Zhao, Ying
Zhang, Li
Dong, Jingde
Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title_full Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title_fullStr Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title_full_unstemmed Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title_short Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
title_sort prevalence and risk factors for malnutrition in patients with parkinson's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758281/
https://www.ncbi.nlm.nih.gov/pubmed/33362679
http://dx.doi.org/10.3389/fneur.2020.533731
work_keys_str_mv AT yangtianting prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhanzhen prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhangliang prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhujun prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT liuyi prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhanglili prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT gejianchao prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhaoying prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT zhangli prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease
AT dongjingde prevalenceandriskfactorsformalnutritioninpatientswithparkinsonsdisease