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Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease
Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758281/ https://www.ncbi.nlm.nih.gov/pubmed/33362679 http://dx.doi.org/10.3389/fneur.2020.533731 |
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author | Yang, Tianting Zhan, Zhen Zhang, Liang Zhu, Jun Liu, Yi Zhang, Lili Ge, Jianchao Zhao, Ying Zhang, Li Dong, Jingde |
author_facet | Yang, Tianting Zhan, Zhen Zhang, Liang Zhu, Jun Liu, Yi Zhang, Lili Ge, Jianchao Zhao, Ying Zhang, Li Dong, Jingde |
author_sort | Yang, Tianting |
collection | PubMed |
description | Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutrition/already malnourished. Questionnaires, physical examinations, and biochemical tests were conducted. The relationship between nutrition status and PD was analyzed using t-tests, χ(2)-tests, and logistic regression models. Results: The prevalence of malnutrition [defined as a Mini Nutritional Assessment (MNA) score <17] was 39.2%, and 30.3% of patients were at risk of malnutrition (17 ≤ MNA score ≤ 23.5). There was no difference in gender and age between the different nutrition groups (P < 0.05). Patients at risk of malnutrition and those who were malnourished had a longer course of disease, more severe motor symptoms, a higher stage of PD according to the Hoehn and Yahr (H-Y) classification, a lower body mass index (BMI) index, a lower cognitive score, higher levels of depression and anxiety, and more serious non-motor symptoms (P < 0.05) than patients with normal nutrition. There were differences in adenosine deaminase, albumin, phosphorus, chlorine, total protein, and uric acid between the two groups (P < 0.05). High Unified PD Rating Scale (UPDRS-III) scores, high H-Y stages, and dyskinesia were risk factors for malnutrition in PD patients, while high levels of total protein, uric acid, and chlorine were protective factors that led to good nutrition (P < 0.05). Conclusions: Our results showed that dyskinesia, disease severity, total protein levels, uric acid levels, and chlorine levels were associated with nutritional status among Chinese PD patients. The findings of this study indicate the significance of the early detection and prevention of malnutrition to improve the quality of life of PD patients. |
format | Online Article Text |
id | pubmed-7758281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77582812020-12-25 Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease Yang, Tianting Zhan, Zhen Zhang, Liang Zhu, Jun Liu, Yi Zhang, Lili Ge, Jianchao Zhao, Ying Zhang, Li Dong, Jingde Front Neurol Neurology Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features. Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutrition/already malnourished. Questionnaires, physical examinations, and biochemical tests were conducted. The relationship between nutrition status and PD was analyzed using t-tests, χ(2)-tests, and logistic regression models. Results: The prevalence of malnutrition [defined as a Mini Nutritional Assessment (MNA) score <17] was 39.2%, and 30.3% of patients were at risk of malnutrition (17 ≤ MNA score ≤ 23.5). There was no difference in gender and age between the different nutrition groups (P < 0.05). Patients at risk of malnutrition and those who were malnourished had a longer course of disease, more severe motor symptoms, a higher stage of PD according to the Hoehn and Yahr (H-Y) classification, a lower body mass index (BMI) index, a lower cognitive score, higher levels of depression and anxiety, and more serious non-motor symptoms (P < 0.05) than patients with normal nutrition. There were differences in adenosine deaminase, albumin, phosphorus, chlorine, total protein, and uric acid between the two groups (P < 0.05). High Unified PD Rating Scale (UPDRS-III) scores, high H-Y stages, and dyskinesia were risk factors for malnutrition in PD patients, while high levels of total protein, uric acid, and chlorine were protective factors that led to good nutrition (P < 0.05). Conclusions: Our results showed that dyskinesia, disease severity, total protein levels, uric acid levels, and chlorine levels were associated with nutritional status among Chinese PD patients. The findings of this study indicate the significance of the early detection and prevention of malnutrition to improve the quality of life of PD patients. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758281/ /pubmed/33362679 http://dx.doi.org/10.3389/fneur.2020.533731 Text en Copyright © 2020 Yang, Zhan, Zhang, Zhu, Liu, Zhang, Ge, Zhao, Zhang and Dong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Yang, Tianting Zhan, Zhen Zhang, Liang Zhu, Jun Liu, Yi Zhang, Lili Ge, Jianchao Zhao, Ying Zhang, Li Dong, Jingde Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title | Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title_full | Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title_fullStr | Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title_full_unstemmed | Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title_short | Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease |
title_sort | prevalence and risk factors for malnutrition in patients with parkinson's disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758281/ https://www.ncbi.nlm.nih.gov/pubmed/33362679 http://dx.doi.org/10.3389/fneur.2020.533731 |
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