A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

A global, quantitative proteomics/systems-biology analysis of the selective pharmacological inhibition of phosphodiesterase-4D (PDE4D) revealed the differential regulation of pathways associated with neuroplasticity in memory-associated brain regions. Subtype selective inhibitors of PDE4D bind in an...

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Detalles Bibliográficos
Autores principales: Wang, Yulu, Gao, Shichao, Zheng, Victor, Chen, Ling, Ma, Min, Shen, Shichen, Qu, Jun, Zhang, Hanting, Gurney, Mark E., O’Donnell, James M., Xu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758534/
https://www.ncbi.nlm.nih.gov/pubmed/33363155
http://dx.doi.org/10.3389/fcell.2020.599389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758534/
https://www.ncbi.nlm.nih.gov/pubmed/33363155
http://dx.doi.org/10.3389/fcell.2020.599389

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