ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion

OBJECTIVES: Type I interferons (IFNs) inhibit regulatory T‐cell (Treg) expansion and activation, making them beneficial in antiviral responses, but detrimental in autoimmune diseases. Herein, we investigate the role of ISG15 in human Tregs in the context of refractoriness to type I IFN stimulation....

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Detalles Bibliográficos
Autores principales: Pacella, Ilenia, Spinelli, Francesca Romana, Severa, Martina, Timperi, Eleonora, Tucci, Gloria, Zagaglioni, Marta, Ceccarelli, Fulvia, Rizzo, Fabiana, Coccia, Eliana M, Patel, Roosheel S, Martin‐Fernandez, Marta, Bogunovic, Dusan, Conti, Fabrizio, Barnaba, Vincenzo, Piconese, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758615/
https://www.ncbi.nlm.nih.gov/pubmed/33376595
http://dx.doi.org/10.1002/cti2.1221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758615/
https://www.ncbi.nlm.nih.gov/pubmed/33376595
http://dx.doi.org/10.1002/cti2.1221

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