Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites

Regeneration of muscle in the damaged myocardium is a major objective of cardiovascular research, for which purpose many investigators utilize mice containing transgenes encoding Cre recombinase to recombine loxP-flanked target genes. An unfortunate side effect of the Cre-loxP model is the propensit...

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Detalles Bibliográficos
Autores principales: Wang, Xinrui, Lauth, Amelia, Wan, Tina C., Lough, John W., Auchampach, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758623/
https://www.ncbi.nlm.nih.gov/pubmed/33106234
http://dx.doi.org/10.1242/dmm.046375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758623/
https://www.ncbi.nlm.nih.gov/pubmed/33106234
http://dx.doi.org/10.1242/dmm.046375

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