Cargando…

Enhanced Affinity for 3-Amino-Chromane-Derived σ(1) Receptor Ligands

[Image: see text] The σ(1) receptor is implicated in regulating a diverse range of physiology and is a target for developing therapies for cancer, pain management, neural degradation, and COVID-19. This report describes 36 phenethylamine-containing 3-amino-chromane ligands, which bind to σ(1) with l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Porter, Matthew R., Xiao, Haiyan, Maity, Sanjay, Vail, Nora, Smith, Sylvia B., Topczewski, Joseph J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758967/ https://www.ncbi.nlm.nih.gov/pubmed/33376910 http://dx.doi.org/10.1021/acsomega.0c05117

Ejemplares similares

Structural basis for σ(1) receptor ligand recognition
por: Schmidt, Hayden R., et al.
Publicado: (2018)

Synthesis of Aminoethyl‐Substituted Piperidine Derivatives as σ(1) Receptor Ligands with Antiproliferative Properties
por: Holtschulte, Catharina, et al.
Publicado: (2022)

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity
por: Torres-Gómez, Héctor, et al.
Publicado: (2021)

Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity
por: Georgiadis, Markos-Orestis, et al.
Publicado: (2017)

Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands
por: Pascarella, Gianmarco, et al.
Publicado: (2023)

Development of New Benzylpiperazine Derivatives as σ(1) Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects
por: Romeo, Giuseppe, et al.
Publicado: (2021)

Metathesis by Partner Interchange in σ‐Bond Ligands: Expanding Applications of the σ‐CAM Mechanism
por: Perutz, Robin N., et al.
Publicado: (2021)

Reactions of salicylaldehyde and enolates or their equivalents: versatile synthetic routes to chromane derivatives
por: Masesane, Ishmael B, et al.
Publicado: (2012)

3-Nitro-2-phenylchroman
por: Zhao, Pei-Hua, et al.
Publicado: (2012)

3-Bromochroman-4-one
por: Shaikh, Mahidansha M., et al.
Publicado: (2013)

6-Chloro-3-[(dimethylamino)methylidene]thiochroman-4-one
por: Khan, Ashraf Y., et al.
Publicado: (2013)

Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
por: Xu, Kuiying, et al.
Publicado: (2022)

Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
por: Rawat, Pinki, et al.
Publicado: (2016)

Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523
por: Li, Jun-Tian, et al.
Publicado: (2011)

Structural Insights into σ(1) Receptor Interactions with Opioid Ligands by Molecular Dynamics Simulations
por: Kurciński, Mateusz, et al.
Publicado: (2018)

(α)N-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
por: Garzón-Niño, Javier, et al.
Publicado: (2022)

Doubly Decarboxylative Synthesis of 4-(Pyridylmethyl)chroman-2-ones and 2-(Pyridylmethyl)chroman-4-ones under Mild Reaction Conditions †
por: Bojanowski, Jan, et al.
Publicado: (2021)

New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
por: Demirayak, Seref, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer
por: Feng, Li, et al.
Publicado: (2021)

Visible-light synthesis of 4-substituted-chroman-2-ones and 2-substituted-chroman-4-ones via doubly decarboxylative Giese reaction
por: Moczulski, Marek, et al.
Publicado: (2021)

Synthesis and Evaluation of Substituted Chroman-4-one and Chromone Derivatives as Sirtuin 2-Selective Inhibitors
por: Fridén-Saxin, Maria, et al.
Publicado: (2012)

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
por: Di Pisa, Flavio, et al.
Publicado: (2017)

Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation
por: Otgon, Oldokh, et al.
Publicado: (2021)

3-Benzylidene-6-methoxychroman-4-one
por: Augustine, T., et al.
Publicado: (2008)

7-Methoxy-2-phenylchroman-4-one
por: Piaskowska, Agata, et al.
Publicado: (2013)

Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones
por: González, Luis A., et al.
Publicado: (2021)

On the Nature of σ–σ, σ–π, and π–π Stacking in Extended Systems
por: Cabaleiro-Lago, Enrique M., et al.
Publicado: (2018)

Characterization of the Effects of Ligands on Bonding and σ-Aromaticity of Small Pt Nanoclusters
por: Reid, Samantha, et al.
Publicado: (2023)

Alternative σ(I)/anti-σ(I) factors represent a unique form of bacterial σ/anti-σ complex
por: Wei, Zhen, et al.
Publicado: (2019)

Evidence of a Bacterial Receptor for Lysozyme: Binding of Lysozyme to the Anti-σ Factor RsiV Controls Activation of the ECF σ Factor σ(V)
por: Hastie, Jessica L., et al.
Publicado: (2014)

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers
por: Bergkemper, Melanie, et al.
Publicado: (2021)

Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

σ(2) Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent
por: Dimić, Dušan S., et al.
Publicado: (2019)

3-(3-Methoxybenzylidene)chroman-4-one
por: Gopaul, Kaalin, et al.
Publicado: (2012)

6-Hydroxy-7,8-dimethylchroman-2-one
por: Goswami, Shailesh K., et al.
Publicado: (2012)

3-Benzyl-5,7-dimethoxychroman-4-ol
por: Shaikh, Mahidansha M., et al.
Publicado: (2011)

3-(3,4-Dichlorobenzylidene)chroman-4-one
por: Gopaul, Kaalin, et al.
Publicado: (2012)

The Bifurcated σ-Hole···σ-Hole Stacking Interactions
por: Zhang, Yu, et al.
Publicado: (2022)

High-affinity fluorescent ligands for the 5-HT(3) receptor
por: Simonin, Jonathan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5o07tp7oor6tus7l0aepkni80n