Population Pharmacodynamic Modeling Using the Sigmoid E(max) Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study

The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathematical models. We investigated the relationship between the steepness of the concentration–effect relationship and inter-individual variability (IIV) of the parameters of the sig...

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Detalles Bibliográficos
Autores principales: Proost, Johannes H., Eleveld, Douglas J., Struys, Michel M. R. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759489/
https://www.ncbi.nlm.nih.gov/pubmed/33367961
http://dx.doi.org/10.1208/s12248-020-00549-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759489/
https://www.ncbi.nlm.nih.gov/pubmed/33367961
http://dx.doi.org/10.1208/s12248-020-00549-7

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