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Population Pharmacodynamic Modeling Using the Sigmoid E(max) Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study
The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathematical models. We investigated the relationship between the steepness of the concentration–effect relationship and inter-individual variability (IIV) of the parameters of the sig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759489/ https://www.ncbi.nlm.nih.gov/pubmed/33367961 http://dx.doi.org/10.1208/s12248-020-00549-7 |