Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques

HIV/SIV persistence in latent reservoirs requires lifelong antiretroviral treatment and calls for effective cure strategies. Romidepsin (RMD), a histone deacetylase inhibitor, was reported to reactivate HIV/SIV from reservoirs in virus-suppressed individuals. We characterized in detail the pharmacok...

Descripción completa

Detalles Bibliográficos
Autores principales: Kleinman, Adam J., Xu, Cuiling, Cottrell, Mackenzie L., Sivanandham, Ranjit, Brocca-Cofano, Egidio, Dunsmore, Tammy, Kashuba, Angela, Pandrea, Ivona, Apetrei, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759686/
https://www.ncbi.nlm.nih.gov/pubmed/33362765
http://dx.doi.org/10.3389/fimmu.2020.579158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759686/
https://www.ncbi.nlm.nih.gov/pubmed/33362765
http://dx.doi.org/10.3389/fimmu.2020.579158

Ejemplares similares