Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the Glo1 gene, serves as the rate-limiting en...

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Detalles Bibliográficos
Autores principales: Šilhavý, Jan, Malínská, Hana, Hüttl, Martina, Marková, Irena, Oliyarnyk, Olena, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Kazdová, Ludmila, Moravcová, Radka, Novotný, Jiří, Pravenec, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759780/
https://www.ncbi.nlm.nih.gov/pubmed/33255888
http://dx.doi.org/10.3390/antiox9121179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759780/
https://www.ncbi.nlm.nih.gov/pubmed/33255888
http://dx.doi.org/10.3390/antiox9121179

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