Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b(5) Activity

Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal samples of different human donors, human recombinant cytochromes P450 (CYPs), flav...

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Detalles Bibliográficos
Autores principales: Indra, Radek, Vavrová, Katarína, Pompach, Petr, Heger, Zbyněk, Hodek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759869/
https://www.ncbi.nlm.nih.gov/pubmed/33260548
http://dx.doi.org/10.3390/biomedicines8120547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759869/
https://www.ncbi.nlm.nih.gov/pubmed/33260548
http://dx.doi.org/10.3390/biomedicines8120547

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