Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive

Toxin B (TcdB) produced by Clostridioides difficile is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein receptors. By using human cervical cancer cel...

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Detalles Bibliográficos
Autores principales: Henkel, Daniel, Tatge, Helma, Schöttelndreier, Dennis, Tao, Liang, Dong, Min, Gerhard, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759879/
https://www.ncbi.nlm.nih.gov/pubmed/33255261
http://dx.doi.org/10.3390/toxins12120736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759879/
https://www.ncbi.nlm.nih.gov/pubmed/33255261
http://dx.doi.org/10.3390/toxins12120736

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