Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial–iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Picca, Anna, Saini, Sunil K., Mankowski, Robert T., Kamenov, George, Anton, Stephen D., Manini, Todd M., Buford, Thomas W., Wohlgemuth, Stephanie E., Xiao, Rui, Calvani, Riccardo, Coelho-Júnior, Hélio José, Landi, Francesco, Bernabei, Roberto, Hood, David A., Marzetti, Emanuele, Leeuwenburgh, Christiaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760001/
https://www.ncbi.nlm.nih.gov/pubmed/33276460
http://dx.doi.org/10.3390/cells9122579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760001/
https://www.ncbi.nlm.nih.gov/pubmed/33276460
http://dx.doi.org/10.3390/cells9122579

Ejemplares similares