Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

SIMPLE SUMMARY: Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in several cellular processes, including the epige...

Descripción completa

Detalles Bibliográficos
Autores principales: Venneker, Sanne, Kruisselbrink, Alwine B., Baranski, Zuzanna, Palubeckaite, Ieva, Briaire-de Bruijn, Inge H., Oosting, Jan, French, Pim J., Danen, Erik H. J., Bovée, Judith V. M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760027/
https://www.ncbi.nlm.nih.gov/pubmed/33266275
http://dx.doi.org/10.3390/cancers12123589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760027/
https://www.ncbi.nlm.nih.gov/pubmed/33266275
http://dx.doi.org/10.3390/cancers12123589

Ejemplares similares