Cargando…

One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [(99m)Tc]Tc-DB4 and [(111)In]In-SG4 in Mice Treated with Entresto

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanellopoulos, Panagiotis, Kaloudi, Aikaterini, Rouchota, Maritina, Loudos, George, de Jong, Marion, Krenning, Eric P., Nock, Berthold A., Maina, Theodosia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760338/ https://www.ncbi.nlm.nih.gov/pubmed/33256013 http://dx.doi.org/10.3390/pharmaceutics12121145

Ejemplares similares

Side-Chain Modified [(99m)Tc]Tc-DT1 Mimics: A Comparative Study in NTS(1)R-Positive Models
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2023)

[(99m)Tc]Tc-DB1 Mimics with Different-Length PEG Spacers: Preclinical Comparison in GRPR-Positive Models
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2020)

[(99m)Tc]Tc-DB15 in GRPR-Targeted Tumor Imaging with SPECT: From Preclinical Evaluation to the First Clinical Outcomes
por: Nock, Berthold A., et al.
Publicado: (2021)

Optimizing the Profile of [(99m)Tc]Tc–NT(7–13) Tracers in Pancreatic Cancer Models by Means of Protease Inhibitors
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2020)

Toward Stability Enhancement of NTS(1)R-Targeted Radioligands: Structural Interventions on [(99m)Tc]Tc-DT1
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2023)

Comparing Gly(11)/dAla(11)-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the (111)In-SB3/(111)In-SB4 Radiotracer Pair
por: Lymperis, Emmanouil, et al.
Publicado: (2019)

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK(2)R Cancer Theranostic Agents: A Preclinical Study
por: Nock, Berthold A., et al.
Publicado: (2022)

Localization of (99m)Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses
por: Kaloudi, Aikaterini, et al.
Publicado: (2019)

[(111)In]In/[(177)Lu]Lu-AAZTA(5)-LM4 SST(2)R-Antagonists in Cancer Theranostics: From Preclinical Testing to First Patient Results
por: Nock, Berthold A., et al.
Publicado: (2023)

Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2020)

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [(111)In-DOTA]MG11—first estimates for clinical translation
por: Kaloudi, Aikaterini, et al.
Publicado: (2016)

[(111)In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study
por: Tatsi, Aikaterini, et al.
Publicado: (2012)

[(68)Ga]Ga-DATA(5m)-LM4, a PET Radiotracer in the Diagnosis of SST(2)R-Positive Tumors: Preclinical and First Clinical Results
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2022)

Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists
por: Nock, Berthold A., et al.
Publicado: (2023)

In vivo imaging techniques for bone tissue engineering
por: Fragogeorgi, Eirini A, et al.
Publicado: (2019)

Is Entresto good for the brain?
por: Patel, Nirav, et al.
Publicado: (2017)

In ®Entresto we trust
por: Camilli, Massimiliano, et al.
Publicado: (2020)

Preclinical pharmacokinetics, biodistribution, radiation dosimetry and toxicity studies required for regulatory approval of a phase I clinical trial with (111)In-CP04 in medullary thyroid carcinoma patients
por: Maina, Theodosia, et al.
Publicado: (2016)

NeoBOMB1, a GRPR-Antagonist for Breast Cancer Theragnostics: First Results of a Preclinical Study with [(67)Ga]NeoBOMB1 in T-47D Cells and Tumor-Bearing Mice
por: Kaloudi, Aikaterini, et al.
Publicado: (2017)

Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics
por: Abouzayed, Ayman, et al.
Publicado: (2023)

Targeting prostate cancer with radiolabelled bombesins
por: Maina, Theodosia, et al.
Publicado: (2006)

Comparison of [(99m)Tc]Tc-tilmanocept with [(99m)Tc]Tc-sulphur colloids and [(99m)Tc]Tc-albumin colloids for sentinel lymph node detection in patients with cutaneous malignancies of the head
por: Ooms, Mark, et al.
Publicado: (2022)

Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines
por: Anam, Mohammad Badrul, et al.
Publicado: (2021)

(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
por: Hayakawa, Takehito, et al.
Publicado: (2018)

[(99m)Tc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic
por: Maurin, Michał, et al.
Publicado: (2022)

Chemistry of the Interaction and Retention of Tc(VII) and Tc(IV) Species at the Fe(3)O(4)(001) Surface
por: Bianchetti, Enrico, et al.
Publicado: (2023)

Optical to Planar X-ray Mouse Image Mapping in Preclinical Nuclear Medicine Using Conditional Adversarial Networks
por: Fysikopoulos, Eleftherios, et al.
Publicado: (2021)

Head to head comparison of [(99m)Tc]Tc(CO)(3)(NTA) and [(99m)Tc]Tc-MAG3 in patients with suspected obstruction
por: Taylor, Andrew T., et al.
Publicado: (2021)

Localization of In-111 Antimyosin Fab and (99m)Tc-Pyrophosphate in Reperfusion Myocardial Infarction Model
por: Lee, Dong Soo, et al.
Publicado: (1990)

Parathyroid adenoma detected with (99m)Tc-tetrofosmin dual-phase scintigraphy: a case report
por: Romanidis, Konstantinos, et al.
Publicado: (2014)

Sentinel lymph node detection in oral cancer: a within-patient comparison between [(99m)Tc]Tc-tilmanocept and [(99m)Tc]Tc-nanocolloid
por: den Toom, Inne J., et al.
Publicado: (2020)

(99m)TcO(4)(-)/(99m)Tc-MIBI dual-tracer scintigraphy for preoperative localization of parathyroid adenomas
por: Huang, Zhongke, et al.
Publicado: (2018)

Initial Experience of Clinical Use of [(99m)Tc]Tc-PSMA-T4 in Patients with Prostate Cancer. A Pilot Study
por: Ćwikła, Jarosław B., et al.
Publicado: (2021)

Optimization of the Pharmacokinetic Profile of [(99m)Tc]Tc-N(4)-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
por: Günther, Thomas, et al.
Publicado: (2022)

Expanding the Knowledge of the Geographic Distribution of Trypanosoma cruzi TcII and TcV/TcVI Genotypes in the Brazilian Amazon
por: Lima, Valdirene dos Santos, et al.
Publicado: (2014)

trans-K(3)[TcO(2)(CN)(4)]
por: Chatterjee, Sayandev, et al.
Publicado: (2010)

4th IFIP TC 5, TC 12, WG 8.4, WG 8.9, WG 12.9 International Cross-Domain Conference
por: Holzinger, Andreas, et al.
Publicado: (2020)

Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4
por: Lenka, Sangram K., et al.
Publicado: (2015)

Memorandum: Division TC
por: Peyrou, Ch
Publicado: (1963)

CERN T.C.
Publicado: (1973)

Cannot write session to /tmp/vufind_sessions/sess_0ch7kjvpfv78emfuemnuscr450