Synthesis, Biological, and Computational Evaluation of Antagonistic, Chiral Hydrobenzoin Esters of Arecaidine Targeting mAChR M1

Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands. Within this work, we synthesized and chemically characterized three differen...

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Detalles Bibliográficos
Autores principales: Ozenil, Marius, Aronow, Jonas, Piljak, Daniela, Vraka, Chrysoula, Holzer, Wolfgang, Spreitzer, Helmut, Wadsak, Wolfgang, Hacker, Marcus, Pichler, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760838/
https://www.ncbi.nlm.nih.gov/pubmed/33266067
http://dx.doi.org/10.3390/ph13120437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760838/
https://www.ncbi.nlm.nih.gov/pubmed/33266067
http://dx.doi.org/10.3390/ph13120437

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