Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a dose-dependent manner. Proteasome activity in the cl...

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Detalles Bibliográficos
Autores principales: Kudriaeva, Anna A., Saratov, George A., Kaminskaya, Alena N., Vladimirov, Vasiliy I., Barzilovich, Petro Yu, Belogurov, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760842/
https://www.ncbi.nlm.nih.gov/pubmed/33255475
http://dx.doi.org/10.3390/biom10121597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760842/
https://www.ncbi.nlm.nih.gov/pubmed/33255475
http://dx.doi.org/10.3390/biom10121597

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