Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activator not interacting with the CAR cavity. In this s...

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Detalles Bibliográficos
Autores principales: Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761063/
https://www.ncbi.nlm.nih.gov/pubmed/33255185
http://dx.doi.org/10.3390/cells9122532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761063/
https://www.ncbi.nlm.nih.gov/pubmed/33255185
http://dx.doi.org/10.3390/cells9122532

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