Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes

Background: Congenital heart defects (CHDs) are present in about 40–60% of newborns with Down syndrome (DS). Patients with DS can also develop acquired cardiac disorders. Mouse models suggest that a critical 3.7 Mb region located on human chromosome 21 (HSA21) could explain the association with CHDs...

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Detalles Bibliográficos
Autores principales: Balistreri, Carmela Rita, Ammoscato, Claudia Leonarda, Scola, Letizia, Fragapane, Tiziana, Giarratana, Rosa Maria, Lio, Domenico, Piccione, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761327/
https://www.ncbi.nlm.nih.gov/pubmed/33260695
http://dx.doi.org/10.3390/genes11121428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761327/
https://www.ncbi.nlm.nih.gov/pubmed/33260695
http://dx.doi.org/10.3390/genes11121428

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