Development of an In Vitro Membrane Model to Study the Function of EsxAB Heterodimer and Establish the Role of EsxB in Membrane Permeabilizing Activity of Mycobacterium tuberculosis

EsxA and EsxB are secreted as a heterodimer and have been shown to play critical roles in phagosome rupture and translocation of Mycobacterium tuberculosis into the cytosol. Recent in vitro studies have suggested that the EsxAB heterodimer is dissociated upon acidification, which might allow EsxA in...

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Detalles Bibliográficos
Autores principales: Vazquez Reyes, Salvador, Ray, Supriyo, Aguilera, Javier, Sun, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761419/
https://www.ncbi.nlm.nih.gov/pubmed/33276541
http://dx.doi.org/10.3390/pathogens9121015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761419/
https://www.ncbi.nlm.nih.gov/pubmed/33276541
http://dx.doi.org/10.3390/pathogens9121015

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