Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

Epithelial to mesenchymal transition (EMT) is associated with resistance during EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. Here, we investigated whether EMT is associated with acquired resistance to 3rd generation EGFR-TKIs, and we explored the effects of cyclin-dependent kinase 7 (CDK7) inh...

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Detalles Bibliográficos
Autores principales: Ji, Wonjun, Choi, Yun Jung, Kang, Myoung-Hee, Sung, Ki Jung, Kim, Dong Ha, Jung, Sangyong, Choi, Chang-Min, Lee, Jae Cheol, Rho, Jin Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761809/
https://www.ncbi.nlm.nih.gov/pubmed/33287368
http://dx.doi.org/10.3390/cells9122596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761809/
https://www.ncbi.nlm.nih.gov/pubmed/33287368
http://dx.doi.org/10.3390/cells9122596

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