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Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

Epithelial to mesenchymal transition (EMT) is associated with resistance during EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. Here, we investigated whether EMT is associated with acquired resistance to 3rd generation EGFR-TKIs, and we explored the effects of cyclin-dependent kinase 7 (CDK7) inh...

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Detalles Bibliográficos
Autores principales:	Ji, Wonjun, Choi, Yun Jung, Kang, Myoung-Hee, Sung, Ki Jung, Kim, Dong Ha, Jung, Sangyong, Choi, Chang-Min, Lee, Jae Cheol, Rho, Jin Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761809/ https://www.ncbi.nlm.nih.gov/pubmed/33287368 http://dx.doi.org/10.3390/cells9122596

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