Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4–Integrin Deficient NOD Mouse

Background: The spontaneously diabetic “non-obese diabetic” (NOD) mouse is a faithful model of human type-1 diabetes (T1D). Methods: Given the pivotal role of α4 integrin (CD49d) in other autoimmune diseases, we generated NOD mice with α4-deficient hematopoiesis (NOD.α4-/-) to study the role of α4 i...

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Detalles Bibliográficos
Autores principales: Oulghazi, Salim, Wegner, Sarah K., Spohn, Gabriele, Müller, Nina, Harenkamp, Sabine, Stenzinger, Albrecht, Papayannopoulou, Thalia, Bonig, Halvard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761835/
https://www.ncbi.nlm.nih.gov/pubmed/33291571
http://dx.doi.org/10.3390/cells9122597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761835/
https://www.ncbi.nlm.nih.gov/pubmed/33291571
http://dx.doi.org/10.3390/cells9122597

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