Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)-8-O-Debutanoylthapsigargin

In spite of the impressing cytotoxicity of thapsigargin (Tg), this compound cannot be used as a chemotherapeutic drug because of general toxicity, causing unacceptable side effects. Instead, a prodrug targeted towards tumors, mipsagargin, was brought into clinical trials. What substantially reduces...

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Detalles Bibliográficos
Autores principales: Zimmermann, Tomáš, Drašar, Pavel, Rimpelová, Silvie, Christensen, Søren Brøgger, Khripach, Vladimir A., Jurášek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762042/
https://www.ncbi.nlm.nih.gov/pubmed/33291419
http://dx.doi.org/10.3390/biom10121640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762042/
https://www.ncbi.nlm.nih.gov/pubmed/33291419
http://dx.doi.org/10.3390/biom10121640

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