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Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage. The aim of our study was to evaluate the neuroprotective potential of ubiquinol by its intravenous administration. The study was perf...

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Autores principales: Olga Nikolaevna, Obolenskaia, Evgeniya Aronovna, Gorodetskaya, Elena Igorevna, Kalenikova, Margarita Alekseevna, Belousova, Mikhail Vladimirovich, Gulyaev, Valery Gennadievich, Makarov, Yury Andreevich, Pirogov, Oleg Stephanovich, Medvedev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762283/
https://www.ncbi.nlm.nih.gov/pubmed/33297323
http://dx.doi.org/10.3390/antiox9121240
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author Olga Nikolaevna, Obolenskaia
Evgeniya Aronovna, Gorodetskaya
Elena Igorevna, Kalenikova
Margarita Alekseevna, Belousova
Mikhail Vladimirovich, Gulyaev
Valery Gennadievich, Makarov
Yury Andreevich, Pirogov
Oleg Stephanovich, Medvedev
author_facet Olga Nikolaevna, Obolenskaia
Evgeniya Aronovna, Gorodetskaya
Elena Igorevna, Kalenikova
Margarita Alekseevna, Belousova
Mikhail Vladimirovich, Gulyaev
Valery Gennadievich, Makarov
Yury Andreevich, Pirogov
Oleg Stephanovich, Medvedev
author_sort Olga Nikolaevna, Obolenskaia
collection PubMed
description Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage. The aim of our study was to evaluate the neuroprotective potential of ubiquinol by its intravenous administration. The study was performed on rats; a stroke was modeled by occlusion of the middle cerebral artery. On days 1 and 4 after ischemia, the neurological deficit and volume of the brain lesion were determined by MRI and TTC staining. Intravenous administration of coenzyme Q10 led to a decrease in rat mortality rate, improvement in neurological status, and decrease in the brain necrosis area in acute and delayed period after cerebral ischemia. A single intravenous administration of ubiquinol led to a limitation of the size of the brain damage for at least four days after ischemia. Thus, intravenous administration of coenzyme Q10 has a persistent neuroprotective potential. This finding suggests a possible therapeutic role of ubiquinol in acute ischemic conditions.
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spelling pubmed-77622832020-12-26 Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model Olga Nikolaevna, Obolenskaia Evgeniya Aronovna, Gorodetskaya Elena Igorevna, Kalenikova Margarita Alekseevna, Belousova Mikhail Vladimirovich, Gulyaev Valery Gennadievich, Makarov Yury Andreevich, Pirogov Oleg Stephanovich, Medvedev Antioxidants (Basel) Article Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage. The aim of our study was to evaluate the neuroprotective potential of ubiquinol by its intravenous administration. The study was performed on rats; a stroke was modeled by occlusion of the middle cerebral artery. On days 1 and 4 after ischemia, the neurological deficit and volume of the brain lesion were determined by MRI and TTC staining. Intravenous administration of coenzyme Q10 led to a decrease in rat mortality rate, improvement in neurological status, and decrease in the brain necrosis area in acute and delayed period after cerebral ischemia. A single intravenous administration of ubiquinol led to a limitation of the size of the brain damage for at least four days after ischemia. Thus, intravenous administration of coenzyme Q10 has a persistent neuroprotective potential. This finding suggests a possible therapeutic role of ubiquinol in acute ischemic conditions. MDPI 2020-12-07 /pmc/articles/PMC7762283/ /pubmed/33297323 http://dx.doi.org/10.3390/antiox9121240 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olga Nikolaevna, Obolenskaia
Evgeniya Aronovna, Gorodetskaya
Elena Igorevna, Kalenikova
Margarita Alekseevna, Belousova
Mikhail Vladimirovich, Gulyaev
Valery Gennadievich, Makarov
Yury Andreevich, Pirogov
Oleg Stephanovich, Medvedev
Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title_full Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title_fullStr Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title_full_unstemmed Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title_short Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model
title_sort intravenous administration of coenzyme q10 in acute period of cerebral ischemia decreases mortality by reducing brain necrosis and limiting its increase within 4 days in rat stroke model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762283/
https://www.ncbi.nlm.nih.gov/pubmed/33297323
http://dx.doi.org/10.3390/antiox9121240
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