Cargando…

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining

The TDP1 (tyrosyl-DNA phosphodiesterase 1) enzyme removes the non-specific covalent intermediates between topoisomerase I and DNA, thus playing a crucial role in preventing DNA damage. While mammals possess only one TDP1 gene, in plants two genes (TDP1α and TDP1β) are present constituting a small ge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mutti, Giacomo, Raveane, Alessandro, Pagano, Andrea, Bertolini, Francesco, Semino, Ornella, Balestrazzi, Alma, Macovei, Anca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762302/ https://www.ncbi.nlm.nih.gov/pubmed/33297410 http://dx.doi.org/10.3390/genes11121465

Ejemplares similares

The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes
por: Macovei, Anca, et al.
Publicado: (2018)

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses
por: Sabatini, Maria Elisa, et al.
Publicado: (2017)

Identification and Characterization of SOG1 (Suppressor of Gamma Response 1) Homologues in Plants Using Data Mining Resources and Gene Expression Profiling
por: Pagano, Andrea, et al.
Publicado: (2022)

Integrative Transcriptomics Data Mining to Explore the Functions of TDP1α and TDP1β Genes in the Arabidopsis thaliana Model Plant
por: Pagano, Paola, et al.
Publicado: (2023)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
por: Zhou, Tong, et al.
Publicado: (2005)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
por: Antony, Smitha, et al.
Publicado: (2007)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
por: Anticevic, Ivan, et al.
Publicado: (2023)

Molecular dynamics of seed priming at the crossroads between basic and applied research
por: Pagano, Andrea, et al.
Publicado: (2023)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
por: Zakharenko, Alexandra L., et al.
Publicado: (2020)

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
por: Zhao, Xue Zhi, et al.
Publicado: (2022)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
por: Zhao, Xue Zhi, et al.
Publicado: (2023)

Ultrastructural and Molecular Analyses Reveal Enhanced Nucleolar Activity in Medicago truncatula Cells Overexpressing the MtTdp2α Gene
por: Macovei, Anca, et al.
Publicado: (2018)

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy
por: Khomenko, Tatyana M., et al.
Publicado: (2019)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

Study of Seed Ageing in lpa1-1 Maize Mutant and Two Possible Approaches to Restore Seed Germination
por: Colombo, Federico, et al.
Publicado: (2023)

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
por: Gushchina, I.V., et al.
Publicado: (2017)

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols
por: Dyrkheeva, Nadezhda, et al.
Publicado: (2020)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2022)

Noninvasive Methods to Detect Reactive Oxygen Species as a Proxy of Seed Quality
por: Griffo, Adriano, et al.
Publicado: (2023)

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019)

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1
por: Flett, Fiona J., et al.
Publicado: (2018)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
por: Zeng, Zhihong, et al.
Publicado: (2011)

Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
por: Cuya, Selma M., et al.
Publicado: (2016)

The Seed Repair Response during Germination: Disclosing Correlations between DNA Repair, Antioxidant Response, and Chromatin Remodeling in Medicago truncatula
por: Pagano, Andrea, et al.
Publicado: (2017)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
por: Lebedeva, Natalia A., et al.
Publicado: (2015)

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
por: Dexheimer, Thomas S., et al.
Publicado: (2010)

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction
por: Adhikari, Sanjay, et al.
Publicado: (2012)

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents
por: Wang, Wenjie, et al.
Publicado: (2019)

Metabolic signatures of germination triggered by kinetin in Medicago truncatula
por: Araújo, Susana, et al.
Publicado: (2019)

Exploring microRNA Signatures of DNA Damage Response Using an Innovative System of Genotoxic Stress in Medicago truncatula Seedlings
por: Gualtieri, Carla, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pkdr0jvfl3bs1s44vcf9dij35b