Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

Non-homologous end-joining (NHEJ) is a DNA repair pathway required to detect, process, and ligate DNA double-stranded breaks (DSBs) throughout the cell cycle. The NHEJ pathway is necessary for V(D)J recombination in developing B and T lymphocytes. During NHEJ, Ku70 and Ku80 form a heterodimer that r...

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Detalles Bibliográficos
Autores principales: Castañeda-Zegarra, Sergio, Zhang, Qindong, Alirezaylavasani, Amin, Fernandez-Berrocal, Marion, Yao, Rouan, Oksenych, Valentyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762521/
https://www.ncbi.nlm.nih.gov/pubmed/33289702
http://dx.doi.org/10.18632/aging.202346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762521/
https://www.ncbi.nlm.nih.gov/pubmed/33289702
http://dx.doi.org/10.18632/aging.202346

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