Cargando…

Aberrant Activity of Histone–Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis

KMT2 (histone-lysine N-methyltransferase subclass 2) complexes methylate lysine 4 on the histone H3 tail at gene promoters and gene enhancers and, thus, control the process of gene transcription. These complexes not only play an essential role in normal development but have also been described as in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poreba, Elzbieta, Lesniewicz, Krzysztof, Durzynska, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762615/ https://www.ncbi.nlm.nih.gov/pubmed/33302406 http://dx.doi.org/10.3390/ijms21249340

Ejemplares similares

Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin
por: Bochyńska, Agnieszka, et al.
Publicado: (2018)

Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer
por: Ding, Beichen, et al.
Publicado: (2019)

Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase
por: Klonou, Alexia, et al.
Publicado: (2021)

Lysine Ethylation by Histone Lysine Methyltransferases
por: Al Temimi, Abbas H. K., et al.
Publicado: (2019)

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors
por: Dhar, Shilpa S., et al.
Publicado: (2021)

Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury
por: Liu, Shu-Bao, et al.
Publicado: (2022)

Lysine methyltransferase Kmt2d regulates naive CD8(+) T cell activation-induced survival
por: Kim, Jaekwan, et al.
Publicado: (2023)

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer
por: Rampias, Theodoros, et al.
Publicado: (2019)

Chemical Probes of Histone Lysine Methyltransferases
por: Kaniskan, H. Ümit, et al.
Publicado: (2014)

KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation
por: Fang, Yang, et al.
Publicado: (2019)

Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration
por: Pacelli, Consiglia, et al.
Publicado: (2020)

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
por: Sharma, Sriganesh B., et al.
Publicado: (2023)

Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression
por: Zhao, Dan, et al.
Publicado: (2023)

Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
por: Al Temimi, Abbas H. K., et al.
Publicado: (2020)

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
por: Trojer, Patrick, et al.
Publicado: (2009)

Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma
por: López, Virginia, et al.
Publicado: (2021)

Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
por: Temimi, Abbas H. K. Al, et al.
Publicado: (2017)

Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
por: Temimi, Abbas H. K. Al, et al.
Publicado: (2020)

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
por: Guo, Changcun, et al.
Publicado: (2013)

Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4
por: Lv, Shidong, et al.
Publicado: (2017)

Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A
por: Meng, Xiang-Min, et al.
Publicado: (2023)

Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D
por: Weiss, Thomas, et al.
Publicado: (2010)

Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif
por: Binda, Olivier
Publicado: (2019)

Role of several histone lysine methyltransferases in tumor development
por: LI, JIFU, et al.
Publicado: (2016)

The role of histone lysine methyltransferase NSD3 in cancer
por: Han, Xu, et al.
Publicado: (2018)

Targets of histone H3 lysine 9 methyltransferases
por: Levinsky, Aidan J., et al.
Publicado: (2022)

The Roles of Histone Lysine Methyltransferases in Heart Development and Disease
por: Zhu, Jun-yi, et al.
Publicado: (2023)

CDC20 Is Regulated by the Histone Methyltransferase, KMT5A, in Castration-Resistant Prostate Cancer
por: Alebady, Zainab A. H., et al.
Publicado: (2023)

Loss of histone H4 lysine 20 trimethylation in osteosarcoma is associated with aberrant expression ofhistone methyltransferase SUV420H2
por: Piao, Lianhua, et al.
Publicado: (2020)

Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer
por: Zhai, Qiliang, et al.
Publicado: (2022)

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder
por: Koemans, Tom S., et al.
Publicado: (2017)

The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration
por: Schwenty-Lara, Janina, et al.
Publicado: (2020)

Histone Methyltransferase KMT2D Regulates H3K4 Methylation and is Involved in the Pathogenesis of Ovarian Cancer
por: Li, Ming, et al.
Publicado: (2021)

Expression Analysis and Mutational Status of Histone Methyltransferase KMT2D at Different Upper Tract Urothelial Carcinoma Locations
por: Laukhtina, Ekaterina, et al.
Publicado: (2021)

KMT1 family methyltransferases regulate heterochromatin–nuclear periphery tethering via histone and non‐histone protein methylation
por: Rao, Radhika Arasala, et al.
Publicado: (2019)

Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma
por: Wang, Xinmiao, et al.
Publicado: (2022)

KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
por: Ang, Siang-Yun, et al.
Publicado: (2016)

Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors
por: Morcillo-Garcia, Sara, et al.
Publicado: (2019)

KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption
por: Assiry, Ali A., et al.
Publicado: (2019)

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer
por: Liu, Lanxin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rlb1e4p8m4vovddt9iic8dm7qr