STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human tau accumulation activated Signal Transduction and Activator of Transcription-1 (STAT1) to i...

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Detalles Bibliográficos
Autores principales: Hong, Xiao-Yue, Wan, Hua-Li, Li, Ting, Zhang, Bing-Ge, Li, Xiao-Guang, Wang, Xin, Li, Xiao, Liu, Qian, Chen, Chong-Yang, Yang, Ying, Wang, Qun, Li, Shu-Peng, Yu, Hao, Wang, Jian-Zhi, Yang, Xi-Fei, Liu, Gong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762755/
https://www.ncbi.nlm.nih.gov/pubmed/33361763
http://dx.doi.org/10.1038/s41392-020-00290-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762755/
https://www.ncbi.nlm.nih.gov/pubmed/33361763
http://dx.doi.org/10.1038/s41392-020-00290-9

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