Comparison of Various Phase I Combination Therapy Designs in Oncology for Evaluation of Early Tumor Shrinkage Using Simulations

There is still a lack of efficient designs for identifying the dose response in oncology combination therapies in early clinical trials. The concentration response relationship can be identified using the early tumor shrinkage time course, which has been shown to be a good early response marker of c...

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Detalles Bibliográficos
Autores principales: Seurat, Jérémy, Girard, Pascal, Goteti, Kosalaram, Mentré, France
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762808/
https://www.ncbi.nlm.nih.gov/pubmed/33080100
http://dx.doi.org/10.1002/psp4.12564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762808/
https://www.ncbi.nlm.nih.gov/pubmed/33080100
http://dx.doi.org/10.1002/psp4.12564

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