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Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins
Intrinsically disordered protein domains often have multiple binding partners. It is plausible that the strength of pairing with specific partners evolves from an initial low affinity to a higher affinity. However, little is known about the molecular changes in the binding mechanism that would facil...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762952/ https://www.ncbi.nlm.nih.gov/pubmed/33454008 http://dx.doi.org/10.1074/jbc.RA120.015645 |