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Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [(99m)TcN](2+) core to obtain the (99m)TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762968/ https://www.ncbi.nlm.nih.gov/pubmed/33322004 http://dx.doi.org/10.3390/molecules25245837 |
Sumario: | In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [(99m)TcN](2+) core to obtain the (99m)TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that (99m)TcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that (99m)TcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to (99m)TcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of (99m)TcN-CPF2XT were higher and the uptakes of (99m)TcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that (99m)TcN-CPF2XT would be a potential bacterial infection imaging agent. |
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