Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent

In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [(99m)TcN](2+) core to obtain the (99m)TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bac...

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Autores principales: Fang, Si’an, Jiang, Yuhao, Gan, Qianqian, Ruan, Qing, Xiao, Di, Zhang, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762968/
https://www.ncbi.nlm.nih.gov/pubmed/33322004
http://dx.doi.org/10.3390/molecules25245837
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author Fang, Si’an
Jiang, Yuhao
Gan, Qianqian
Ruan, Qing
Xiao, Di
Zhang, Junbo
author_facet Fang, Si’an
Jiang, Yuhao
Gan, Qianqian
Ruan, Qing
Xiao, Di
Zhang, Junbo
author_sort Fang, Si’an
collection PubMed
description In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [(99m)TcN](2+) core to obtain the (99m)TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that (99m)TcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that (99m)TcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to (99m)TcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of (99m)TcN-CPF2XT were higher and the uptakes of (99m)TcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that (99m)TcN-CPF2XT would be a potential bacterial infection imaging agent.
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spelling pubmed-77629682020-12-27 Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent Fang, Si’an Jiang, Yuhao Gan, Qianqian Ruan, Qing Xiao, Di Zhang, Junbo Molecules Article In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [(99m)TcN](2+) core to obtain the (99m)TcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that (99m)TcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that (99m)TcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to (99m)TcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of (99m)TcN-CPF2XT were higher and the uptakes of (99m)TcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that (99m)TcN-CPF2XT would be a potential bacterial infection imaging agent. MDPI 2020-12-10 /pmc/articles/PMC7762968/ /pubmed/33322004 http://dx.doi.org/10.3390/molecules25245837 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fang, Si’an
Jiang, Yuhao
Gan, Qianqian
Ruan, Qing
Xiao, Di
Zhang, Junbo
Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title_full Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title_fullStr Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title_full_unstemmed Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title_short Design, Preparation, and Evaluation of a Novel (99m)TcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent
title_sort design, preparation, and evaluation of a novel (99m)tcn complex of ciprofloxacin xanthate as a potential bacterial infection imaging agent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762968/
https://www.ncbi.nlm.nih.gov/pubmed/33322004
http://dx.doi.org/10.3390/molecules25245837
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